PLK1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA596158

Catalog No. PIPA596158

Description

Immunogen sequence: FFTSGYIPAR LPITCLTIPP RFSIAPSSLD PSNRKPLTVL NKGLENPLPE RPREKEEPVV RETGEVVDCH LSDMLQQLHS VNASKPSERG LVRQEEAEDP ACIPIFWVSK WVDYSDKYGL GYQLCDNSVG VLFNDSTRLI LYNDGDSLQY IERDGTESYL TVSSHPNSLM KKITLLKYFR NYMSEHLLKA GANITPREGD ELARLPYLRT WFRTRSAIIL HLSNGSVQIN FFQDHTKLIL CPLMAAVTYI DEKRDFRTYR LSLLEEYGCC KELASRLRYA RTMVDKLLSS RSASNRLKAS; Positive Samples: HeLa, HepG2, SKOV3, SGC-7901, Mouse testis; Cellular Location: Chromosome, Cytoplasm, Midbody, Nucleus, centromere, centrosome, cytoskeleton, kinetochore, microtubule organizing center, spindle

PLK1 is a serine/threonine kinase that is thought to function in cell mitosis and regarded as a marker of cell proliferation. It has been found to play a critical role in carcinogenesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, PPP1R12A/MYPT1, PRC1, RACGAP1/CYK4, SGOL1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1 and WEE1. Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL.

Specifications

• Antigen: PLK1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Plk1
• Gene Alias: cell cycle regulated protein kinase, Plk, PLK 1, Plk1, PLK-1, plk1.S, plx1, polo (Drosophia)-like kinase, polo like kinase, polo like kinase 1, polo like kinase 1 S homeolog, polo-like kinase, polo-like kinase 1, polo-like kinase homolog, polo-like protein kinase, serine/threonine-protein kinase 13, Serine/threonine-protein kinase PLK1, STPK13, STPK14, Unknown (protein for MGC:133927), XELAEV_18047692mg
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18817, 25515, 5347
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.89 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
• Gene Accession No.: P53350, Q07832, Q62673
• Gene Symbols: Plk1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 304-603 of human PLK1 (NP_0050212)
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov