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Invitrogen™ PLK1 Recombinant Rabbit Monoclonal Antibody (8R4D9)
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Catalog No. FEMA551231
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100 μL
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FEMA551231 100 μL
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Catalog No. FEMA551231 Supplier Invitrogen™ Supplier No. MA551231
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Description

Rabbit Recombinant Monoclonal Antibody

Immunogen sequence: KHINPVAASL IQKMLQTDPT ARPTINELLN DEFFTSGYIP ARLPITCLTI PPRFSIAPSS LDPSNRKPLT VLNKGLENPL PERPREKEEP VVRETGEVVD CHLSDMLQQL HSVNASKPSE RGLVRQEEAE DPACIPIFWV SKWVDYSDKY GLGYQLCDNS VGVLFNDSTR LILYNDGDSL QYIERDGTES YLTVSSHPNS LMKKITLLKY FRNYMSEHLL KAGA.

PLK1 is a serine/threonine kinase that is thought to function in cell mitosis and regarded as a marker of cell proliferation. It has been found to play a critical role in carcinogenesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, PPP1R12A/MYPT1, PRC1, RACGAP1/CYK4, SGOL1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1 and WEE1. Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PLK1
Applications ELISA, Western Blot
Classification Recombinant Monoclonal
Clone 8R4D9
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Plk1
Gene Accession No. P53350, Q07832, Q62673
Gene Alias cell cycle regulated protein kinase; Plk; PLK 1; Plk1; PLK-1; plk1.S; plx1; polo (Drosophia)-like kinase; polo like kinase; polo like kinase 1; polo like kinase 1 S homeolog; polo-like kinase; polo-like kinase 1; polo-like kinase homolog; polo-like protein kinase; serine/threonine-protein kinase 13; Serine/threonine-protein kinase PLK1; STPK13; STPK14; Unknown (protein for MGC:133927); XELAEV_18047692mg
Gene Symbols Plk1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 272-495 of human PLK1 (NP_005021.2).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18817, 25515, 5347
Target Species Human, Mouse, Rat, Monkey
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Format Liquid
Isotype IgG
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