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Invitrogen™ PLK5 Polyclonal Antibody
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Catalog No. PIPA5101864
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100 μL
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PIPA5101864 100 μL
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Catalog No. PIPA5101864 Supplier Invitrogen™ Supplier No. PA5101864
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total PLK5.

Polo-like kinase 5 (PLK5) is a member of the Polo-like kinase family, notable for its involvement in cell cycle regulation processes such as mitotic entry, spindle formation, and cytoplasmic division. PLK5 is distinguished from other family members by its low expression levels, particularly within different immunophenotypes, except for being notably elevated in the C5 subtype. Its expression has been linked to poor prognosis in non-small cell lung cancer, although this is not universally supported by all data sources, suggesting complex roles in tumor biology. In a mouse model, PLK5 functions as a DNA damage-inducible gene with nucleolar localization, facilitated by a specific nucleolus localization signal in its N-terminal. The protein's ectopic expression can lead to G1 phase arrest, indicating its role in cellular response to DNA damage. Research is ongoing to fully elucidate its function and prognostic implications across various cancer types.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PLK5
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Plk5
Gene Accession No. Q496M5
Gene Alias 6330514A18Rik; FG060302; Inactive serine/threonine-protein kinase PLK5; PLK5; PLK-5; PLK5P; polo like kinase 5; polo-like kinase 5; polo-like kinase 5 pseudogene; polo-like kinase 5, pseudogene; serine/threonine-protein kinase PLK5; SgK384ps
Gene Symbols Plk5
Host Species Rabbit
Immunogen A synthesized peptide derived from human PLK5(Accession Q496M5), corresponding to amino acid residues W203-L253.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 126520
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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