Invitrogen™ PLK5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA557120

Catalog No. PIPA557120

Description

Immunogen sequence: YTVLTGTPPF MASPLSEMYQ NIREGHYPEP AHLSANARRL IVHLLAPNPA ERPSLDHLLQ DDFFTQ Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 79%.

Polo-like kinase 5 (PLK5) is a member of the Polo-like kinase family, notable for its involvement in cell cycle regulation processes such as mitotic entry, spindle formation, and cytoplasmic division. PLK5 is distinguished from other family members by its low expression levels, particularly within different immunophenotypes, except for being notably elevated in the C5 subtype. Its expression has been linked to poor prognosis in non-small cell lung cancer, although this is not universally supported by all data sources, suggesting complex roles in tumor biology. In a mouse model, PLK5 functions as a DNA damage-inducible gene with nucleolar localization, facilitated by a specific nucleolus localization signal in its N-terminal. The protein's ectopic expression can lead to G1 phase arrest, indicating its role in cellular response to DNA damage. Research is ongoing to fully elucidate its function and prognostic implications across various cancer types.

Specifications

• Antigen: PLK5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Plk5
• Gene Alias: 6330514A18Rik; FG060302; Inactive serine/threonine-protein kinase PLK5; PLK5; PLK-5; PLK5P; polo like kinase 5; polo-like kinase 5; polo-like kinase 5 pseudogene; polo-like kinase 5, pseudogene; serine/threonine-protein kinase PLK5; SgK384ps
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 126520
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q496M5
• Gene Symbols: Plk5
• Immunogen: Recombinant protein corresponding to Human PLK5. Recombinant protein control fragment (Product #RP-97250).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov