PLOD2 Monoclonal Antibody (OTI1A12), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA803169

Catalog No. 50-167-9608

Description

The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.

Specifications

• Antigen: PLOD2
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: O00469
• Gene Symbols: PLOD2
• Immunogen: Human recombit protein fragment corresponding to amino acids 359-640 of human PLOD2 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: OTI1A12
• Conjugate: Unconjugated
• Gene: PLOD2
• Gene Alias: BRKS2, LH2, TLH
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5352
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid