PLOD2 Mouse anti-Human, Clone: OTI7G5, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF803225

Catalog No. 50-166-6383

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.

Specifications

• Antigen: PLOD2
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: PLOD2
• Gene Alias: BRKS2, LH2, TLH
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5352
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI7G5
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: O00469
• Gene Symbols: PLOD2
• Immunogen: Human recombit protein fragment corresponding to amino acids 359-640 of human PLOD2 produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a