Invitrogen™ PLP1 Monoclonal Antibody (plpc 1)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA190652

Catalog No. PIMA190652

Description

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

PLP1 is a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene.This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene.

Specifications

• Antigen: PLP1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.09% sodium azide
• Gene Accession No.: P04116, P60201, P60202
• Gene Symbols: PLP1
• Immunogen: Synthetic peptide-amino acids CGRGTKF corresponding to C terminal region of myelin proteolipid protein.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Bovine, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: plpc 1
• Conjugate: Unconjugated
• Gene: PLP1
• Gene Alias: DM20; GPM6C; HLD1; jimpy; jp; lipophilin; lipophilin (aa 129 to 276); major myelin proteolipid protein; MMPL; msd; Myelin proteolipid protein; myelin synthesis deficiency; PLP; PLP/DM20; Plp1; PMD; proteolipid; proteolipid protein; proteolipid protein (myelin) 1; Proteolipid protein (Pelizaeus-Merzbacher disease spastic paraplegia 2 uncomplicated); Proteolipid protein (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated); proteolipid protein 1; proteolipid protein 1 (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated); proteolipid protein, lipophilin; rsh; rump shaker; SPG2
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 18823, 281410, 5354
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid