Invitrogen™ PLP1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA3150

Catalog No. PA3150

Description

PA3-150 detects proteolipid protein in mouse samples. PA3-150 has been used successfully in Western blot and immunocytochemistry procedures. By Western blot this antibody detects a ~26-29 kDa protein representing the proteolipid protein in adult mouse brain samples. The PA3-150 immunogen is a synthetic peptide corresponding to residues C(109) G K G L S A T V T G G Q K G R G S R G(128) of PLP.

PLP1 is a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene.This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene.

Specifications

• Antigen: PLP1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PLP1
• Gene Alias: DM20; GPM6C; HLD1; jimpy; jp; lipophilin; lipophilin (aa 129 to 276); major myelin proteolipid protein; MMPL; msd; Myelin proteolipid protein; myelin synthesis deficiency; PLP; PLP/DM20; Plp1; PMD; proteolipid; proteolipid protein; proteolipid protein (myelin) 1; Proteolipid protein (Pelizaeus-Merzbacher disease spastic paraplegia 2 uncomplicated); Proteolipid protein (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated); proteolipid protein 1; proteolipid protein 1 (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated); proteolipid protein, lipophilin; rsh; rump shaker; SPG2
• Host Species: Rabbit
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot, Immunocytochemistry
• Concentration: Conc. Not Determined
• Formulation: Whole Serum with 0.05% sodium azide
• Gene Accession No.: P60202
• Gene Symbols: PLP1
• Immunogen: Synthetic peptide corresponding to residues C(109) G K G L S A T V T G G Q K G R G S R G(128) of PLP.
• Regulatory Status: RUO
• Gene ID (Entrez): 18823
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid