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Invitrogen™ PLSCR1 Polyclonal Antibody
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Catalog No. PIPA575633
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100 μL
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PIPA575633 100 μL
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Catalog No. PIPA575633 Supplier Invitrogen™ Supplier No. PA575633
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Description

Rabbit Polyclonal Antibody

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

The calcium-dependent plasma membrane protein phospholipid scramblase 1 (PLSCR1) contributes to the transbilayer movement of phosphatidylserine and other membrane phospholipids upon influx of calcium into the cytosol. This movement results in plasma membrane phospholipid remodelling and surface exposure of phosphatidylserine in injured or apoptotic cells, which leads to cell death. Interferons and other cytokines induce expression of PLSCR1, implying that PLSCR1 also functions in cytokine signaling pathways. EGF stilmulation results in tyrosine phosphorylation of PLSCR1 on tyrosines 69 and 74, which allows it to interact with Shc, and thereby connecting Src kinase activation to stimulation of the EGF receptor.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PLSCR1
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene PLSCR1
Gene Accession No. O15162, P58195, Q9JJ00
Gene Alias ca(2+)-dependent phospholipid scramblase 1; Erythrocyte phospholipid scramblase; MmTRA1a; MmTRA1b; NOR1; Phospholipid scramblase 1; phospholipid scramblase 2; PL scramblase 1; Plscr1; Tra1; Tra1a; Tra1b; transplantability-associated protein 1; Tras1; Tras2
Gene Symbols PLSCR1
Host Species Rabbit
Immunogen Synthetic peptide corresponding to residues in Human PLSCR1.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 117540, 22038, 5359
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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