Invitrogen™ PLSCR3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120153

Catalog No. PIPA5120153

Description

Positive test controls include: A-549, 293T, HepG2, BxPC-3, HeLa, Mouse brain, Mouse heart, Mouse kidney. The target is usually found in the following locations: Mitochondrion membrane, Single-pass type II membrane protein. Immunogen sequence: MAGYLPPKGY APSPPPPYPV TPGYPEPALH PGPGQAPVPA QVPAPAPGFA LFPSPGPVAL GSAAPFLPLP GVPSGLEFLV QIDQILIHQK AERVETFLGW ETCNRYELRS GAGQPLGQAA EESNCCARLC CGARRPLRVR LADPGDREVL RLLRPLHCGC SCCPCGLQEM EVQAPPGTTI GHVLQTWHPF LPKFSIQDAD RQTVLRVVGP CWTCGCGTDT NFEVKTRDES RSVGRISKQW GGLVREALTD ADDFGLQFPL DLDVRVKAVL LGATFLIDYM FFEKRGGAGP SAVTS.

May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Seems to play a role in apoptosis, through translocation of cardiolipin from the inner to the outer mitochondrial membrane which promotes BID recruitment and enhances tBid-induced mitochondrial damages. [UniProt].

Specifications

• Antigen: PLSCR3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Plscr3
• Gene Alias: 2210403O21Rik; 2610037N06Rik; Ca 2+ dependent phospholipid scramblase 3; ca(2+)-dependent phospholipid scramblase 3; ESTM3; LOW QUALITY PROTEIN: phospholipid scramblase 3; LOW QUALITY PROTEIN: phospholipid scramblase 3; phospholipid scramblase 3; phospholipid scramblase 3; PL scramblase 3; Pls3; Plscr3; Unknown (protein for MGC:138060); X83310
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 360549, 57048, 70310
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 1.98 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q6QBQ4, Q9JIZ9, Q9NRY6
• Gene Symbols: Plscr3
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-295 of human PLSCR3 (NP_065093.2).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG