Invitrogen™ PLXNA3 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA547571

Catalog No. PIPA547571

Description

In direct ELISAs and Western blots, less than 5% cross-reactivity with recombinant mouse (rm) Plexin A1, rmPlexin A2, recombinant human (rh) Plexin B1, rhPlexin C1, and rhPlexin D1 is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.

Specifications

• Antigen: PLXNA3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Plxna3
• Gene Alias: 6.3; HSSEXGENE; mKIAA4078; PlexA3; plexin 3; Plexin 4, SEX, homolog to the cMet/HGF receptors; plexin A3; plexin-4; Plexin-A3; Plxa3; Plxn3; Plxn4; Plxna3; Semaphorin receptor SEX; SEX; Sex chromosome X transmembrane protein of HGF receptor family 3; SEXPLEXIN-A3; XAP-6
• Host Species: Goat
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18846, 309280
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: D3ZPX4, P70208
• Gene Symbols: Plxna3
• Immunogen: E. coli-derived recombinant mouse Plexin A3 Leu34-Asp150.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgG