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Invitrogen™ EXOSC10 Polyclonal Antibody
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Catalog No. PIPA528589
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100 μL
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Catalog No. Quantity
PIPA528589 100 μL
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Catalog No. PIPA528589 Supplier Invitrogen™ Supplier No. PA528589
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: Raji, EXOSC10-transfected 293T. Predicted reactivity: Mouse (92%), Chicken (82%), Chimpanzee (99%), Bovine (94%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

About 50% of patients with polymyositis/scleroderma (PM-Scl) overlap syndrome are reported to have autoantibodies to a nuclear/nucleolar particle termed PM-Scl. Exosome component 10 (EXOSC10), also named autoantigen PM/Scl-2, is the 100 kDa antigen component of PM-Scl and is recognized by most sera of PM-Scl patients. EXOSC10 is strongly enriched in the nucleolus and a small amount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form. As a putative catalytic component ofthe RNA exosome complex which has 3'->5' exoribonuclease activity, EXOSC10 participates in a multitude of cellular RNA processing and degradation events.
TRUSTED_SUSTAINABILITY

Specifications

Antigen EXOSC10
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1.0 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Gene EXOSC10
Gene Accession No. Q01780
Gene Alias Autoantigen PM/Scl 2; Autoantigen PM/Scl 2 homolog; autoantigen PM-SCL; Exosc10; Exosome component 10; P100 polymyositis-scleroderma overlap syndrome-associated autoantigen; p2; p3; p4; PM/Scl-100; PMSCL; PM-Scl; PMSCL2; Polymyositis/scleroderma autoantigen 100 kDa; polymyositis/scleroderma autoantigen 2; Polymyositis/scleroderma autoantigen 2 homolog; RRP6; Rrp6p
Gene Symbols EXOSC10
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human EXOSC10. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5394
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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