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Invitrogen™ EXOSC10 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA555873
Description
Immunogen sequence: FAHPYQYELN HFTPADAVLQ KPQPQLYRPI EETPCHFISS LDELVELNEK LLNCQEFAVD LEHHSYRSFL GLTCLMQIST RTEDF Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 89%.
About 50% of patients with polymyositis/scleroderma (PM-Scl) overlap syndrome are reported to have autoantibodies to a nuclear/nucleolar particle termed PM-Scl. Exosome component 10 (EXOSC10), also named autoantigen PM/Scl-2, is the 100 kDa antigen component of PM-Scl and is recognized by most sera of PM-Scl patients. EXOSC10 is strongly enriched in the nucleolus and a small amount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form. As a putative catalytic component ofthe RNA exosome complex which has 3'->5' exoribonuclease activity, EXOSC10 participates in a multitude of cellular RNA processing and degradation events.
Specifications
EXOSC10 | |
Polyclonal | |
Unconjugated | |
EXOSC10 | |
Autoantigen PM/Scl 2; Autoantigen PM/Scl 2 homolog; autoantigen PM-SCL; Exosc10; Exosome component 10; P100 polymyositis-scleroderma overlap syndrome-associated autoantigen; p2; p3; p4; PM/Scl-100; PMSCL; PM-Scl; PMSCL2; Polymyositis/scleroderma autoantigen 100 kDa; polymyositis/scleroderma autoantigen 2; Polymyositis/scleroderma autoantigen 2 homolog; RRP6; Rrp6p | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
5394 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry (Paraffin), Immunocytochemistry | |
0.4 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
Q01780 | |
EXOSC10 | |
Recombinant protein corresponding to Human PM-Scl. Recombinant protein control fragment (Product #RP-94455). | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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