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Invitrogen™ EXOSC10 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier: Invitrogen™ PA5100508

Catalog No. PIPA5100508

$559.50 / Each of 1

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Description

Antibody detects endogenous levels of total EXOSC10.

About 50% of patients with polymyositis/scleroderma (PM-Scl) overlap syndrome are reported to have autoantibodies to a nuclear/nucleolar particle termed PM-Scl. Exosome component 10 (EXOSC10), also named autoantigen PM/Scl-2, is the 100 kDa antigen component of PM-Scl and is recognized by most sera of PM-Scl patients. EXOSC10 is strongly enriched in the nucleolus and a small amount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form. As a putative catalytic component ofthe RNA exosome complex which has 3'->5' exoribonuclease activity, EXOSC10 participates in a multitude of cellular RNA processing and degradation events.

Specifications

Antigen	EXOSC10
Classification	Polyclonal
Conjugate	Unconjugated
Gene	EXOSC10
Gene Alias	Autoantigen PM/Scl 2; Autoantigen PM/Scl 2 homolog; autoantigen PM-SCL; Exosc10; Exosome component 10; P100 polymyositis-scleroderma overlap syndrome-associated autoantigen; p2; p3; p4; PM/Scl-100; PMSCL; PM-Scl; PMSCL2; Polymyositis/scleroderma autoantigen 100 kDa; polymyositis/scleroderma autoantigen 2; Polymyositis/scleroderma autoantigen 2 homolog; RRP6; Rrp6p
Host Species	Rabbit
Purification Method	Affinity chromatography
Regulatory Status	RUO
Gene ID (Entrez)	313707, 50912, 5394
Content And Storage	-20°C
Form	Liquid

Applications	Immunohistochemistry (Paraffin), Western Blot
Concentration	1 mg/mL
Formulation	PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.	P56960, Q01780
Gene Symbols	EXOSC10
Immunogen	A synthesized peptide derived from human EXOSC10(Accession Q01780), corresponding to amino acid residues T196-T246.
Quantity	100 μL
Primary or Secondary	Primary
Target Species	Human, Mouse, Rat
Product Type	Antibody
Isotype	IgG

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Invitrogen™ EXOSC10 Polyclonal Antibody

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