Invitrogen™ PMCA2 ATPase Polyclonal Antibody

Catalog No.	Quantity
PIPA593257	100 μL

Catalog No. PIPA593257 Supplier Invitrogen™ Supplier No. PA593257

Description

Rabbit Polyclonal Antibody

Immunogen sequence: MGDMTNSDFY SKNQRNESSH GGEFGCTMEE LRSLMELRGT EAVVKIKETY GDTEAICRRL KTSPVEGLPG TAPDLEKRKQ; Positive Samples: Mouse ovary, Mouse lung, Mouse liver, Rat liver; Cellular Location: Cell junction, Cell membrane, Multi-pass membrane protein, synapse.

The calcium pump of the plasma membrane, termed PMCA ATPase, pumps calcium from the cytosol to the extracellular space. This membrane-bound enzyme is related to a number of other ATPases including the SERCA ATPase and the sodium/K+ pump. There are four different genes encoding PMCA ATPase and studies have revealed 20 isoforms of the pump generated by alternate splicing of the primary gene products. mRNA distribution studies show that gene products 1 and 4 are transcribed in most tissues, however, products 2 and 3 are more tissue specific. Transcription of the splicing variants has also been found to be tissue specific. In the pancreas, where insulin secretion is calcium dependent, the beta cells only express the 4b isoform, however the alpha and gamma cells express both 4a and 4b isoforms. Studies have also shown that different splice variants have different affinities for calcium and calmodulin.

Specifications

• Antigen: PMCA2 ATPase
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 1.56 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: ATP2B2
• Gene Accession No.: P11506, Q01814, Q9R0K7
• Gene Alias: Atp2b2; ATPase isoform 2 Na+K+ transporting beta polypeptide 2; ATPase isoform 2, Na+K+ transporting, beta polypeptide 2; ATPase plasma membrane Ca2+ transporting 2; ATPase, Ca++ transporting, plasma membrane 2; D6Abb2e; deaf waddler; dfw; Gena300; jog; plasma membrane Ca(2+)-ATPase; plasma membrane Ca++-ATPase; plasma membrane Ca2+ pump 2; plasma membrane calcium ATPase; Plasma membrane calcium ATPase isoform 2; plasma membrane calcium pump; Plasma membrane calcium pump isoform 2; Plasma membrane calcium-transporting ATPase 2; PMCA2; PMCA2a; PMCA2i; Tmy; wms; wri; wriggle
• Gene Symbols: ATP2B2
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human ATP2B2 (NP_0016742).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 11941, 24215, 491
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG