Invitrogen™ PMCA4 ATPase Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA587634

Catalog No. PIPA587634

Description

Immunogen sequence: ELPRTPLLDE EEEENPDKAS KFGTRVLLLD GEVTPYANTN NNAVDCNQVQ LPQSDSSLQS LETSV; Positive Samples: Mouse brain; Cellular Location: Cell membrane, Cell projection, Multi-pass membrane protein, cilium, flagellum membrane.

The calcium pump of the plasma membrane, termed PMCA ATPase, pumps calcium from the cytosol to the extracellular space. This membrane-bound enzyme is related to a number of other ATPases including the SERCA ATPase and the sodium/K+ pump. There are four different genes encoding PMCA ATPase and studies have revealed 20 isoforms of the pump generated by alternate splicing of the primary gene products. mRNA distribution studies show that gene products 1 and 4 are transcribed in most tissues, however, products 2 and 3 are more tissue specific. Transcription of the splicing variants has also been found to be tissue specific. In the pancreas, where insulin secretion is calcium dependent, the beta cells only express the 4b isoform, however the alpha and gamma cells express both 4a and 4b isoforms. Studies have also shown that different splice variants have different affinities for calcium and calmodulin (Cat. # MA3-917 and MA3-918).

Specifications

• Antigen: PMCA4 ATPase
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Atp2b4
• Gene Alias: ATP2B2; ATP2B4; ATPase plasma membrane Ca2+ transporting 4; ATPase, Ca++ transporting, plasma membrane 4; ATPase, Ca++ transporting, plasma membrane 4 ATP synthase, H+ transporting, mitochondrial F1; ATPase, Ca++ transporting, plasma membrane 4 tv2; matrix-remodeling-associated protein 1; MXRA1; plasma membrane Ca2+-ATPases 4; plasma membrane calcium ATPase; plasma membrane calcium ATPase 4; plasma membrane calcium ATPase 4 variant b; Plasma membrane calcium ATPase isoform 4; plasma membrane calcium pump; Plasma membrane calcium pump isoform 4; plasma membrane calcium-pumping ATP-ase; plasma membrane calcium-transporting ATPase 4; PMCA4; PMCA4b; PMCA4x; sarcolemmal calcium pump
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 381290
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.95 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q6Q477
• Gene Symbols: Atp2b4
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1141-1205 of human ATP2B4 (NP_0016753).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG