Invitrogen™ PML Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA588263

Catalog No. PIPA588263

Description

Positive Samples: DU145; Cellular Location: Cytoplasm, Cytoplasmic side, Early endosome membrane, Endoplasmic reticulum membrane, Nucleus, PML body, Peripheral membrane protein, nucleolus, nucleoplasm Immunogen sequence: AVDARYQRDY EEMASRLGRL DAVLQRIRTG SALVQRMKCY ASDQEVLDMH GFLRQALCRL RQEEPQSLQA AVRTDGFDEF KVRLQDLSSC ITQGKDAAVS KKASPEAAST PRDPIDVDLP EEAERVKAQV QALGLAEAQP MAVVQSVPGA HPVPVYAFSI KGPSYGEDVS NTTTAQKRKC SQTQCPRKVI KMESEEGKEA RLARSSPEQP RPSTSKAVSP PHLDGPPSPR SPVIGSEVFL PNSNHVASGA GEAEERVVVI SSSEDSDAEN SSSRELDDSS SESSDLQLEG PSTLRVLDEN L.

The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair (NER). This protein was shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, as well as with ubiquitin protein ligase E6AP, and thus suggests that this protein may be involved in the ubiquitin mediated proteolytic pathway in cells.

Specifications

• Antigen: PML
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PML
• Gene Alias: 1200009E24Rik; AI661194; MYL; Pml; PML/RARA fusion; pml1; PP8675; probable transcription factor PML; promyelocytic leukemia; promyelocytic leukemia protein; promyelocytic leukemia, inducer of; protein PML; RGD1562602; RING finger protein 71; RNF71; TRIM19; tripartite motif protein TRIM19; tripartite motif-containing protein 19
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5371
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 2.42 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P29590
• Gene Symbols: PML
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 300-600 of human PML (NP_1502412).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG