Invitrogen™ PMP70 Polyclonal Antibody, Alexa Fluor™ 647

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA1650A647

Catalog No. PIPA1650AY

Description

PA1650A647 immunizing peptide corresponds to amino acid residues 644-659 from rat PMP70. This sequence is completely conserved in mouse PMP70 and differs from human PMP70 by a single amino acid substitution. The immunizing peptide (Cat. # PEP-038) is available for use in neutralization and control experiments.

Peroxisomes are single membrane organelles which are involved with many important biochemical pathways and are found in almost all eukaryotic cells. Various toxins including, phenols, alcohols, and aldehydes are targeted for modification by peroxisomes. Long chain fatty acid metabolism via beta-oxidation is also mediated by this organelle. Loss of peroxisomal functions may result in diseases such as Zellweger syndrome, hyperpipecolic acidemia, neonatal adrenoleukodystrophy, and infantile Refsum disease. Peroxisomal membrane protein 70 (PMP70) is an abundant, integral membrane protein of the peroxisome. This protein is induced by treatment with hypolipidemic agents in parallel with peroxisome proliferation and stimulation of the peroxisomal beta-oxidation enzymes.

Specifications

• Antigen: PMP70
• Classification: Polyclonal
• Conjugate: Alexa Fluor 647
• Gene: ABCD3
• Gene Alias: 68 kDa peroxisomal membrane protein; 70 kDa peroxisomal membrane protein; 70-kDa peroxisomal membrane protein; ABC43; ABCD3; AI313901; ATP binding cassette subfamily D member 3; ATP-binding cassette sub-family D member 3; ATP-binding cassette, subfamily D (ALD), member 3; ATP-binding cassette, sub-family D (ALD), member 3; AU018866; AW146054; CBAS5; dJ824O18.1 (ATP-binding cassette, sub-family D (ALD), member 3 (PMP70, PXMP1)); Peroxisomal membrane protein 1; peroxisomal membrane protein 1 (70kD, Zellweger syndrome); peroxisomal membrane protein, 70 kDa; Peroxisomal membrane protein-1 (70kD); PMP68; Pmp70; Pxmp1; ZWS2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 19299, 25270, 5825
• Content And Storage: 4°C, store in dark, DO NOT FREEZE!
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 1mg/mL BSA and 0.05% sodium azide; pH 7.4
• Gene Accession No.: P16970, P28288, P55096
• Gene Symbols: ABCD3
• Immunogen: Synthetic Peptide: C N(644) Y E F K K I T E D T V E F G S(659).
• Quantity: 50 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov