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PMS2 Mouse anti-Human, Clone: OTI2G5, liquid, TrueMAB™
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene TA506658S

Encompass_Preferred

Catalog No. 50-167-6714


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Description

Description

Mismatch DNA repair in bacteria is carried out by the MutL, MutH, and MutS proteins. The MutS protein initially binds to mismatched DNA. This is followed by binding of the MutH endonuclease and MutL to form a complex that carries out excision repair. The hMSH2 gene specifies a MutS homologue and hMLH1, hPMS1, and hPMS2 encode MutL homologs. Mutations in these genes are associated with hereditary nonpolyposis colon cancer (HNPCC), one of the most common hereditary diseases in man. As with the bacterial system, HNPCC is characterized by frequent microsatellite mutations that arise by somatic mutation due to a replication error (RER+) phenotype. Both hPMS1 and hPMS2 are mutated in the germline of HNPCC patients. Although the exact function of MutL and its homologs has yet to be determined, it is known that a complex of PMS2 and MLH1 (MutLa) from HeLa cells can complement a deficiency of MLH1 in hypermutable H6 colorectal tumor cells.
Specifications

Specifications

PMS2
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
P54278
PMS2
Full length human recombit protein of human PMS2 produced in HEK293T cell.
30 μL
Primary
Human
Antibody
IgG2b
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
OTI2G5
Unconjugated
PMS2
HNPCC4, MLH4, PMS2CL, PMSL2
Mouse
Affinity Chromatography
RUO
5395
-20° C, Avoid Freeze/Thaw Cycles
Liquid
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