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Invitrogen™ PMS2/PMS2CL Polyclonal Antibody
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Catalog No. PIPA5106710
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100 μL
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PIPA5106710 100 μL
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Catalog No. PIPA5106710 Supplier Invitrogen™ Supplier No. PA5106710
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total PMS2/PMS2CL.

Mismatch DNA repair in bacteria is carried out by the MutL, MutH, and MutS proteins. The MutS protein initially binds to mismatched DNA. This is followed by binding of the MutH endonuclease and MutL to form a complex that carries out excision repair. The hMSH2 gene specifies a MutS homologue and hMLH1, hPMS1, and hPMS2 encode MutL homologs. Mutations in these genes are associated with hereditary nonpolyposis colon cancer (HNPCC), one of the most common hereditary diseases in man. As with the bacterial system, HNPCC is characterized by frequent microsatellite mutations that arise by somatic mutation due to a replication error (RER+) phenotype. Both hPMS1 and hPMS2 are mutated in the germline of HNPCC patients. Although the exact function of MutL and its homologs has yet to be determined, it is known that a complex of PMS2 and MLH1 (MutLa) from HeLa cells can complement a deficiency of MLH1 in hypermutable H6 colorectal tumor cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PMS2/PMS2CL
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene PMS2CL
Gene Accession No. P54278, Q68D20
Gene Alias DNA mismatch repair protein PMS2; H_DJ0042M02.9; HNPCC4; mismatch repair endonuclease PMS2; MLH4; PMS1 homolog 2, mismatch repair protein; PMS1 homolog 2, mismatch repair system component; PMS1 protein homolog 2; PMS2; PMS2 C-terminal like pseudogene; PMS2 postmeiotic segregation increased 2; PMS2CL; PMS2P13; PMSL2; postmeiotic segregation increased 2 nirs variant 6
Gene Symbols PMS2, PMS2CL
Host Species Rabbit
Immunogen A synthesized peptide derived from human PMS2CL(Accession Q68D20), corresponding to amino acid residues D124-C174.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 441194, 5395
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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