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  5. Tocris Bioscience™ PND 1186

Tocris Bioscience™ PND 1186
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Catalog No. 689110
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent FAK inhibitor; orally bioavailable

PND 1186 is a potent FAK inhibitor (IC50 values are 1.5 and 100 nM for recombinant FAK and FAK in breast carcinoma cells, respectively). Promotes caspase activation; triggering apoptosis. Inhibits 4T1 breast carcinoma subcutaneous tumor growth and breast carcinoma cell motility. Decreases spontaneous breast to lung metastasis in pre-clinical models. Orally bioavailable.

Specifications

Quantity 10 mg
Molecular Formula C25H26F3N5O3
Formula Weight 501.51
Product Type Inhibitor
Purity 98%
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