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Invitrogen™ PNK Polyclonal Antibody
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Catalog No. PIPA582263
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100 μL
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PIPA582263 100 μL
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Catalog No. PIPA582263 Supplier Invitrogen™ Supplier No. PA582263
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: PETRTVAVKQ LGVNPSTTGT QELKPGLEGS LGVGDTLYLV NGLHPLTLRW EETRTPESQP DTPPGTPLVS QDEKRDAELP KKRMRKSNPG WENLEKLLVF TAAGVKPQGK VAGFDLDGTL ITTRSGKVFP TGP Highest antigen sequence indentity to the following orthologs: Mouse - 76%, Rat - 77%.

Anti-human Polynucleotide Kinase Mouse Monoclonal Antibody recognizes polynucleotide kinase (PNK), a 57 kDa nuclear enzyme implicated in DNA strand repair processes that occur during DNA replication and recombination, or in response to DNA damaging agents. PNK targets the DNA 5'-hydroxy and 3'-phosphate termini for phosphorylation and dephosphorylation events. During strand breakage in human cells, normal PNK associates with other nuclear proteins to prepare the DNA termini for the enzymatic actions of DNA polymerase-beta and DNA ligase III. PNK is a key functional component in maintaining the genetic stability of human cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PNK
Applications Immunohistochemistry (Paraffin), Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Pnkp
Gene Accession No. Q96T60
Gene Alias 1810009G08Rik; 2'(3')-polynucleotidase; AOA4; bifunctional polynucleotide phosphatase/kinase; DNA 5'-kinase/3'-phosphatase; EIEE10; Homo sapiens polynucleotide kinase 3'-phosphatase (PNKP); MCSZ; phosphatase/kinase; PKNP; PNK; PNKP; Polynucleotide 3'-phosphatase; Polynucleotide 5'-hydroxyl-kinase; polynucleotide kinase 3'- phosphatase; polynucleotide kinase 3'-phosphatase; polynucleotide kinase-3'-phosphatase
Gene Symbols Pnkp
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human PNKP. Recombinant protein control fragment (Product #a href=.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11284
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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