Invitrogen™ PNK Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA582263

Catalog No. PIPA582263

Description

Immunogen sequence: PETRTVAVKQ LGVNPSTTGT QELKPGLEGS LGVGDTLYLV NGLHPLTLRW EETRTPESQP DTPPGTPLVS QDEKRDAELP KKRMRKSNPG WENLEKLLVF TAAGVKPQGK VAGFDLDGTL ITTRSGKVFP TGP.

Anti-human Polynucleotide Kinase Mouse Monoclonal Antibody recognizes polynucleotide kinase (PNK), a 57 kDa nuclear enzyme implicated in DNA strand repair processes that occur during DNA replication and recombination, or in response to DNA damaging agents. PNK targets the DNA 5'-hydroxy and 3'-phosphate termini for phosphorylation and dephosphorylation events. During strand breakage in human cells, normal PNK associates with other nuclear proteins to prepare the DNA termini for the enzymatic actions of DNA polymerase-beta and DNA ligase III. PNK is a key functional component in maintaining the genetic stability of human cells.

Specifications

• Antigen: PNK
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Pnkp
• Gene Alias: 1810009G08Rik; 2'(3')-polynucleotidase; AOA4; bifunctional polynucleotide phosphatase/kinase; DNA 5'-kinase/3'-phosphatase; EIEE10; Homo sapiens polynucleotide kinase 3'-phosphatase (PNKP); MCSZ; phosphatase/kinase; PKNP; PNK; PNKP; Polynucleotide 3'-phosphatase; Polynucleotide 5'-hydroxyl-kinase; polynucleotide kinase 3'- phosphatase; polynucleotide kinase 3'-phosphatase; polynucleotide kinase-3'-phosphatase
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11284
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunohistochemistry, Western Blot
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q96T60
• Gene Symbols: Pnkp
• Immunogen: Recombinant protein corresponding to Human PNKP. Recombinant protein control fragment (Product #a href=.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG