Invitrogen™ PNN Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA535053

Catalog No. PIPA535053

Description

This antibody is predicted to react with bovine and mouse based on sequence homology.

Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Component of the PSAP complex which binds RNA in a sequence-independent manner and is proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma. [UniProt].

Specifications

• Antigen: PNN
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PNN
• Gene Alias: 140 kDa nuclear and cell adhesion-related phosphoprotein; AU045199; D12Ertd512e; Desmosome-associated protein; domain-rich serine protein; DRS; DRS protein; DRSP; fb24d03; Melanoma metastasis clone A protein; memA; neutrophil protein; nuclear protein SDK3; Pinin; pinin, desmosome associated protein; PNN; PNN protein; SDK3; SR-like protein; wu:fb24d03
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography, Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 5411
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.25 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene Accession No.: Q9H307
• Gene Symbols: PNN
• Immunogen: KLH conjugated synthetic peptide between 209-239 amino acids from the central region of human PNN.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov