Invitrogen™ PNP Polyclonal Antibody

Catalog No.	Quantity
PIPA551616	100 μL

Catalog No. PIPA551616 Supplier Invitrogen™ Supplier No. PA551616

Description

Rabbit Polyclonal Antibody

Immunogen sequence: YTYEDYKNTA EWLLSHTKHR PQVAIICGSG LGGLTDKLTQ AQIFDYGEIP NFPRSTVPGH AGRLVFGFLN GRACVMMQGR FHMYEGYPLW KVTFPVRVFH LLGVDTLVVT NAAGGLNPKF EVGDIMLIRD HINLPGFSGQ NPLRGPNDER GAPHR Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 87%.

The PNP gene encodes for the enzyme purine nucleoside phosphorylase, which plays a vital role in the purine salvage pathway by catalyzing the reversible cleavage of purine nucleosides. This enzyme facilitates the conversion of inosine, guanosine, and deoxyguanosine into free bases and sugars phosphorylated at the C1 position. PNP is located on chromosome 14q13 and is crucial for nucleoside catabolism, impacting energy metabolism and cellular functions across various organisms. PNP deficiency is an autosomal recessive multisystem disorder arising from mutations in the PNP gene, leading to impaired T-cell maturation and function, resulting in recurrent infections, autoimmune manifestations, and neurological abnormalities due to the toxic accumulation of deoxyguanosine triphosphate (dGTP). This deficiency particularly affects immature thymocytes and can lead to lymphoid and neuronal toxicity, underscoring the gene's importance in proper immune system function and cellular health.

Specifications

• Antigen: PNP
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: PNP
• Gene Accession No.: P00491, P23492, P85973
• Gene Alias: AL024301; AU015798; endothelial dysfunction inducing protein; epididymis secretory sperm binding protein Li 156an; HEL-S-156an; inosine phosphorylase; inosine phosphorylase {ECO:0000250; Inosine-guanosine phosphorylase; Np; Np-1; Np-2; nucleoside phosphorylase; PNP; PNP {ECO:0000250; Pnp1; PRO1837; PUNP; purine nucleoside phosphorylase; purine nucleoside phosphorylase {ECO:0000250; purine-nucleoside phosphorylase; purine-nucleoside phosphorylase 1; purine-nucleoside:orthophosphate ribosyltransferase; UniProtKB:P00491}
• Gene Symbols: PNP
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to Human PNP. Recombinant protein control fragment (Product #RP-98841).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 18950, 290029, 4860
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG