Invitrogen™ PNP Recombinant Rabbit Monoclonal Antibody (103)

Catalog No.	Quantity
PIMA529491	100 μL

Catalog No. PIMA529491

Supplier: Invitrogen™ MA529491

Description

Rabbit Recombinant Monoclonal Antibody

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%). Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire. This antibody has specificity for Human Purine nucleoside phosphorylase/PNP.

The PNP gene encodes for the enzyme purine nucleoside phosphorylase, which plays a vital role in the purine salvage pathway by catalyzing the reversible cleavage of purine nucleosides. This enzyme facilitates the conversion of inosine, guanosine, and deoxyguanosine into free bases and sugars phosphorylated at the C1 position. PNP is located on chromosome 14q13 and is crucial for nucleoside catabolism, impacting energy metabolism and cellular functions across various organisms. PNP deficiency is an autosomal recessive multisystem disorder arising from mutations in the PNP gene, leading to impaired T-cell maturation and function, resulting in recurrent infections, autoimmune manifestations, and neurological abnormalities due to the toxic accumulation of deoxyguanosine triphosphate (dGTP). This deficiency particularly affects immature thymocytes and can lead to lymphoid and neuronal toxicity, underscoring the gene's importance in proper immune system function and cellular health.

Specifications

• Antigen: PNP
• Applications: ELISA, Immunoprecipitation, Western Blot
• Classification: Recombinant Monoclonal
• Clone: 103
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with no preservative
• Gene: PNP
• Gene Accession No.: P00491
• Gene Alias: AL024301; AU015798; endothelial dysfunction inducing protein; epididymis secretory sperm binding protein Li 156an; HEL-S-156an; inosine phosphorylase; inosine phosphorylase {ECO:0000250; Inosine-guanosine phosphorylase; Np; Np-1; Np-2; nucleoside phosphorylase; PNP; PNP {ECO:0000250; Pnp1; PRO1837; PUNP; purine nucleoside phosphorylase; purine nucleoside phosphorylase {ECO:0000250; purine-nucleoside phosphorylase; purine-nucleoside phosphorylase 1; purine-nucleoside:orthophosphate ribosyltransferase; UniProtKB:P00491}
• Gene Symbols: PNP
• Host Species: Rabbit
• Immunogen: Recombinant Human Purine nucleoside phosphorylase/PNP protein (Met1-Ser289).
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 4860
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG