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Invitrogen™ PNPase Polyclonal Antibody
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Catalog No. PIPA583235
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100 μL
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PIPA583235 100 μL
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Catalog No. PIPA583235 Supplier Invitrogen™ Supplier No. PA583235
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: FMPLVVDYRQ KAAAAGRIPT NYLRREIGTS DKEILTSRII DRSIRPLFPA GYFYDTQVLC NLLAVDGVNE PDVLAINGAS VALSLSDIPW NGPVGAVR Highest antigen sequence indentity to the following orthologs: Mouse - 93%, Rat - 95%.

PNPT1 (polyribonucleotide nucleotidyltransferase 1, mitochondirla) is a RNA-binding protein implicated in numerous RNA metabolic processes. It catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction. PNPT1 is a component of the mitochondrial degradosome (mtEXO) complex that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. It is required for correct processing and polyadenylation of mitochondrial mRNAs. It plays a role as a cytoplasmic RNA import factor, in mitochondrial morphogenesis and respiration, regulation of expression of the electron transport chain, regulation of the stability of specific mature miRNAs in melanoma cells, and RNA cell surveilance. Mutations of the gene can result in combined oxidative phosphorylation deficiency 13 (COXPD13) and deafness, autosomal recessive, 70 (DFNB70).
TRUSTED_SUSTAINABILITY

Specifications

Antigen PNPase
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene PNPT1
Gene Accession No. Q8TCS8
Gene Alias 1200003F12Rik; 3'-5' RNA exonuclease OLD35; COXPD13; DFNB70; DKFZp762K1914; old 35; Old35; old-35; PNPase; PNPase 1; PNPase old-35; Pnpt1; Pnptl1; polynucleotide phosphorylase 1; Polynucleotide phosphorylase-like protein; polyribonucleotide nucleotidyltransferase 1; polyribonucleotide nucleotidyltransferase 1, mitochondrial
Gene Symbols PNPT1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human PNPT1. Recombinant protein control fragment (Product #RP-102624).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 87178
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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