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Invitrogen™ PNPase Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA522397

Catalog No. PIPA522397


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Description

Description

Recommended positive controls: 293T, A431, HeLa, HepG2. Predicted reactivity: Mouse (92%), Rat (93%), Pig (93%), Bovine (93%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

PNPT1 (polyribonucleotide nucleotidyltransferase 1, mitochondirla) is a RNA-binding protein implicated in numerous RNA metabolic processes. It catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction. PNPT1 is a component of the mitochondrial degradosome (mtEXO) complex that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. It is required for correct processing and polyadenylation of mitochondrial mRNAs. It plays a role as a cytoplasmic RNA import factor, in mitochondrial morphogenesis and respiration, regulation of expression of the electron transport chain, regulation of the stability of specific mature miRNAs in melanoma cells, and RNA cell surveilance. Mutations of the gene can result in combined oxidative phosphorylation deficiency 13 (COXPD13) and deafness, autosomal recessive, 70 (DFNB70).
TRUSTED_SUSTAINABILITY
Specifications

Specifications

PNPase
Polyclonal
Unconjugated
PNPT1
1200003F12Rik; 3'-5' RNA exonuclease OLD35; COXPD13; DFNB70; DKFZp762K1914; old 35; Old35; old-35; PNPase; PNPase 1; PNPase old-35; Pnpt1; Pnptl1; polynucleotide phosphorylase 1; Polynucleotide phosphorylase-like protein; polyribonucleotide nucleotidyltransferase 1; polyribonucleotide nucleotidyltransferase 1, mitochondrial
Rabbit
Antigen Affinity Chromatography
RUO
87178
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
1 mg/mL
PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Q8TCS8
PNPT1
Recombinant fragment corresponding to a region within amino acids 1 and 783 of PNPase (Uniprot ID#Q8TCS8).
100 μL
Primary
Human
Antibody
IgG
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