PNPT1 Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-7729	100 μL

Catalog No. 50-198-7729 Supplier Bioss Supplier No. BS7100R

Description

Rabbit Polyclonal Antibody

PNPT1 (polyribonucleotide nucleotidyltransferase 1, mitochondirla) is a RNA-binding protein implicated in numerous RNA metabolic processes. It catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3′-to-5′ direction. PNPT1 is a component of the mitochondrial degradosome (mtEXO) complex that degrades 3′ overhang double-stranded RNA with a 3′-to-5′ directionality in an ATP-dependent manner. It is required for correct processing and polyadenylation of mitochondrial mRNAs. It plays a role as a cytoplasmic RNA import factor, in mitochondrial morphogenesis and respiration, regulation of expression of the electron transport chain, regulation of the stability of specific mature miRNAs in melanoma cells, and RNA cell surveilance. Mutations of the gene can result in combined oxidative phosphorylation deficiency 13 (COXPD13) and deafness, autosomal recessive, 70 (DFNB70).

Specifications

• Antigen: PNPT1
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: PNPT1
• Gene Accession No.: Q8TCS8
• Gene Alias: 1200003F12Rik; 3′-5′ RNA exonuclease OLD35; BOS_11603; COXPD13; DFNB70; DKFZp762K1914; old 35; Old35; old-35; PNPASE; PNPase 1; PNPase old-35; Pnpt1; Pnptl1; Polynucleotide phosphorylase 1; Polynucleotide phosphorylase-like protein; polyribonucleotide nucleotidyltransferase 1; Polyribonucleotide nucleotidyltransferase 1, mitochondrial
• Gene Symbols: PNPT1
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human PNPT1.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 87178
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG