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PNPT1 Rabbit anti-Human, Polyclonal, Bioss
SDP

Rabbit Polyclonal Antibody

Supplier:  Bioss BS7100R

Encompass_Preferred

Catalog No. 50-198-7729


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Description

Description

PNPT1 (polyribonucleotide nucleotidyltransferase 1, mitochondirla) is a RNA-binding protein implicated in numerous RNA metabolic processes. It catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3′-to-5′ direction. PNPT1 is a component of the mitochondrial degradosome (mtEXO) complex that degrades 3′ overhang double-stranded RNA with a 3′-to-5′ directionality in an ATP-dependent manner. It is required for correct processing and polyadenylation of mitochondrial mRNAs. It plays a role as a cytoplasmic RNA import factor, in mitochondrial morphogenesis and respiration, regulation of expression of the electron transport chain, regulation of the stability of specific mature miRNAs in melanoma cells, and RNA cell surveilance. Mutations of the gene can result in combined oxidative phosphorylation deficiency 13 (COXPD13) and deafness, autosomal recessive, 70 (DFNB70).
Specifications

Specifications

PNPT1
Polyclonal
Unconjugated
PNPT1
1200003F12Rik; 3′-5′ RNA exonuclease OLD35; BOS_11603; COXPD13; DFNB70; DKFZp762K1914; old 35; Old35; old-35; PNPASE; PNPase 1; PNPase old-35; Pnpt1; Pnptl1; Polynucleotide phosphorylase 1; Polynucleotide phosphorylase-like protein; polyribonucleotide nucleotidyltransferase 1; Polyribonucleotide nucleotidyltransferase 1, mitochondrial
Rabbit
Protein A
RUO
87178
-20°C
Liquid
Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
1 μg/mL
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Q8TCS8
PNPT1
KLH conjugated synthetic peptide derived from human PNPT1.
100 μL
Primary
Human
Antibody
IgG
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