Invitrogen™ PODN Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA599862

Catalog No. PIPA599862

Description

Antibody detects endogenous levels of total PODN.

Non-collagenous proteins of the small leucine-rich repeat (SLR) protein family are considered important components of the extracellular matrix. The extracellular matrix plays an integral role in the pivotal processes of development, tissue repair and metastasis by regulating cell proliferation, differentiation, adhesion and migration. Podocan, also known as PCAN, SLRR5A or PODN, is a 613 amino acid secreted protein belonging to the small leucine-rich proteoglycan (SLRP) family and the class V subfamily. Expressed in kidney, heart, liver, pancreas and vascular smooth muscle cells, Podocan exists as three alternatively spliced isoforms containing twenty LRR (leucine-rich repeats), a unique N-terminal cysteine-rich cluster pattern and a highly acidic C-terminal domain. Podocan is considered a glycoprotein containing N-linked oligosaccharides that may be involved in growth regulation in cardiovascular tissues. Encoded by a gene located on human chromosome 1, Podocan interacts type I collagen (COL1).

Specifications

• Antigen: PODN
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Podn
• Gene Alias: 9430070G18; Pcan; Podn; Podocan; podocan proteoglycan; PRO332; SLRR5A; UNQ293; UNQ293/PRO332
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 127435
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q7Z5L7
• Gene Symbols: Podn
• Immunogen: A synthesized peptide derived from human PODN(Accession Q7Z5L7), corresponding to amino acid residues V66-L116.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov