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Invitrogen™ Podocin Monoclonal Antibody (C3), Invitrogen™

Catalog No. PIMA543646
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100 μL
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PIMA543646 20 μL
PIMA543645 100 μL
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Catalog No. PIMA543646 Supplier Invitrogen™ Supplier No. MA543646
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Description

Mouse Monoclonal Antibody

The pathological conditions of SRN1 correlate well with mutations at the NPHS2 gene, where expression of a protein known as Podocin occurs. Abnormal or inefficient signaling through Podocin protein-dependent networks contributes to the development of podocyte dysfunction and proteinuria. The human NPHS2 gene maps to chromosome 1q25-q31 and encodes a 383 amino acid protein. Podocin is an integral membrane protein that appears to fold into a hairpin-like structure with intracellular amino- and carboxy-termini. Transmembrane and cytoplasmic portions of Podocin share homology to the corresponding regions of the stomatin family proteins. Expression of high-order oligomers of Podocin in glomerular podocytes may reflect a scaffolding function that influences proper function of the glomerular filtration barrier, which is necessary for renal stability.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Podocin
Applications Western Blot
Classification Monoclonal
Clone C3
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
Gene Nphs2
Gene Accession No. Q8K4G9, Q91X05, Q9NP85
Gene Alias AI790225; nephrosis 2 homolog, podocin; nephrosis 2 idiopathic steroid-resistant (podocin); nephrosis 2, idiopathic, steroid-resistant; nephrosis 2, idiopathic, steroid-resistant (podocin); nephrosis 2, podocin; NPHS2; NPHS2 podocin; NPHS2 stomatin family member, podocin; NPHS2, podocin; PDCN; podocin; SRN1
Gene Symbols Nphs2
Host Species Mouse
Immunogen Met222-Pro372 (Accession Q9NP85), with N-terminal His Tag.
Purification Method Protein A/G
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 170484, 170672, 7827
Target Species Human, Mouse, Rat, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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