Invitrogen™ Podocin Monoclonal Antibody (C3), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA543646

Catalog No. PIMA543646

Description

The pathological conditions of SRN1 correlate well with mutations at the NPHS2 gene, where expression of a protein known as Podocin occurs. Abnormal or inefficient signaling through Podocin protein-dependent networks contributes to the development of podocyte dysfunction and proteinuria. The human NPHS2 gene maps to chromosome 1q25-q31 and encodes a 383 amino acid protein. Podocin is an integral membrane protein that appears to fold into a hairpin-like structure with intracellular amino- and carboxy-termini. Transmembrane and cytoplasmic portions of Podocin share homology to the corresponding regions of the stomatin family proteins. Expression of high-order oligomers of Podocin in glomerular podocytes may reflect a scaffolding function that influences proper function of the glomerular filtration barrier, which is necessary for renal stability.

Specifications

• Antigen: Podocin
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
• Gene Accession No.: Q8K4G9, Q91X05, Q9NP85
• Gene Symbols: Nphs2
• Immunogen: Met222-Pro372 (Accession Q9NP85), with N-terminal His Tag.
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Rat
• Product Type: Antibody
• Isotype: IgG2a κ

• Applications: Western Blot
• Clone: C3
• Conjugate: Unconjugated
• Gene: Nphs2
• Gene Alias: AI790225; nephrosis 2 homolog, podocin; nephrosis 2 idiopathic steroid-resistant (podocin); nephrosis 2, idiopathic, steroid-resistant; nephrosis 2, idiopathic, steroid-resistant (podocin); nephrosis 2, podocin; NPHS2; NPHS2 podocin; NPHS2 stomatin family member, podocin; NPHS2, podocin; PDCN; podocin; SRN1
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 170484, 170672, 7827
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid