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Invitrogen™ Podocin Recombinant Rabbit Monoclonal Antibody (2O10G3)
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Catalog No. PIMA542776
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100 μL
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PIMA542776 100 μL
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Catalog No. PIMA542776 Supplier Invitrogen™ Supplier No. MA542776
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Description

Rabbit Recombinant Monoclonal Antibody

Positive test controls include: HeLa, HT-29, 293T. Immunogen sequence: AQRQAKVRMI AAEAEKAASE SLRMAAEILS GTPAAVQLRY LHTLQSLSTE KPSTVVLPLP FDLLNCLSSP SNRTQGSLPF PSPSKPVEPL NPKKKDSPML.

The pathological conditions of SRN1 correlate well with mutations at the NPHS2 gene, where expression of a protein known as Podocin occurs. Abnormal or inefficient signaling through Podocin protein-dependent networks contributes to the development of podocyte dysfunction and proteinuria. The human NPHS2 gene maps to chromosome 1q25-q31 and encodes a 383 amino acid protein. Podocin is an integral membrane protein that appears to fold into a hairpin-like structure with intracellular amino- and carboxy-termini. Transmembrane and cytoplasmic portions of Podocin share homology to the corresponding regions of the stomatin family proteins. Expression of high-order oligomers of Podocin in glomerular podocytes may reflect a scaffolding function that influences proper function of the glomerular filtration barrier, which is necessary for renal stability.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Podocin
Applications ELISA, Western Blot
Classification Recombinant Monoclonal
Clone 2O10G3
Concentration 1.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Nphs2
Gene Accession No. Q8K4G9, Q9NP85
Gene Alias AI790225; nephrosis 2 homolog, podocin; nephrosis 2 idiopathic steroid-resistant (podocin); nephrosis 2, idiopathic, steroid-resistant; nephrosis 2, idiopathic, steroid-resistant (podocin); nephrosis 2, podocin; NPHS2; NPHS2 podocin; NPHS2 stomatin family member, podocin; NPHS2, podocin; PDCN; podocin; SRN1
Gene Symbols Nphs2
Host Species Rabbit
Immunogen Synthetic peptide.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 170672, 7827
Target Species Human, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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