Invitrogen™ Podocin Recombinant Rabbit Monoclonal Antibody (2O10G3)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA542776

Catalog No. PIMA542776

Description

Positive test controls include: HeLa, HT-29, 293T. Immunogen sequence: AQRQAKVRMI AAEAEKAASE SLRMAAEILS GTPAAVQLRY LHTLQSLSTE KPSTVVLPLP FDLLNCLSSP SNRTQGSLPF PSPSKPVEPL NPKKKDSPML.

The pathological conditions of SRN1 correlate well with mutations at the NPHS2 gene, where expression of a protein known as Podocin occurs. Abnormal or inefficient signaling through Podocin protein-dependent networks contributes to the development of podocyte dysfunction and proteinuria. The human NPHS2 gene maps to chromosome 1q25-q31 and encodes a 383 amino acid protein. Podocin is an integral membrane protein that appears to fold into a hairpin-like structure with intracellular amino- and carboxy-termini. Transmembrane and cytoplasmic portions of Podocin share homology to the corresponding regions of the stomatin family proteins. Expression of high-order oligomers of Podocin in glomerular podocytes may reflect a scaffolding function that influences proper function of the glomerular filtration barrier, which is necessary for renal stability.

Specifications

• Antigen: Podocin
• Classification: Recombinant Monoclonal
• Concentration: 1.2 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q8K4G9, Q9NP85
• Gene Symbols: Nphs2
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 284-383 of human NPHS2 (Q9NP85).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Western Blot
• Clone: 2O10G3
• Conjugate: Unconjugated
• Gene: Nphs2
• Gene Alias: AI790225; nephrosis 2 homolog, podocin; nephrosis 2 idiopathic steroid-resistant (podocin); nephrosis 2, idiopathic, steroid-resistant; nephrosis 2, idiopathic, steroid-resistant (podocin); nephrosis 2, podocin; NPHS2; NPHS2 podocin; NPHS2 stomatin family member, podocin; NPHS2, podocin; PDCN; podocin; SRN1
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 170672, 7827
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid