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Invitrogen™ Podocin Recombinant Rabbit Monoclonal Antibody (JB51-33)
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Catalog No. PIMA534674
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PIMA534674 100 μL
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Catalog No. PIMA534674 Supplier Invitrogen™ Supplier No. MA534674
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Description

Rabbit Recombinant Monoclonal Antibody

Positive Control: Rat kidney tissue, human kidney tissue, mouse kidney tissue, 293T.

The pathological conditions of SRN1 correlate well with mutations at the NPHS2 gene, where expression of a protein known as Podocin occurs. Abnormal or inefficient signaling through Podocin protein-dependent networks contributes to the development of podocyte dysfunction and proteinuria. The human NPHS2 gene maps to chromosome 1q25-q31 and encodes a 383 amino acid protein. Podocin is an integral membrane protein that appears to fold into a hairpin-like structure with intracellular amino- and carboxy-termini. Transmembrane and cytoplasmic portions of Podocin share homology to the corresponding regions of the stomatin family proteins. Expression of high-order oligomers of Podocin in glomerular podocytes may reflect a scaffolding function that influences proper function of the glomerular filtration barrier, which is necessary for renal stability.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Podocin
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Classification Recombinant Monoclonal
Clone JB51-33
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with 40% glycerol, 0.05% BSA and 0.05% sodium azide; pH 7.4
Gene Nphs2
Gene Accession No. Q91X05, Q9NP85
Gene Alias AI790225; nephrosis 2 homolog, podocin; nephrosis 2 idiopathic steroid-resistant (podocin); nephrosis 2, idiopathic, steroid-resistant; nephrosis 2, idiopathic, steroid-resistant (podocin); nephrosis 2, podocin; NPHS2; NPHS2 podocin; NPHS2 stomatin family member, podocin; NPHS2, podocin; PDCN; podocin; SRN1
Gene Symbols Nphs2
Host Species Rabbit
Immunogen Synthetic peptide within Human NPHS2 aa 334-383.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 170484, 7827
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles, store in dark
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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