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  6. Invitrogen™ Podoplanin Monoclonal Antibody (eBio8.1.1 (8.1.1)), PerCP-eFluor™ 710, eBioscience™, Invitrogen™ 

Invitrogen™ Podoplanin Monoclonal Antibody (eBio8.1.1 (8.1.1)), PerCP-eFluor™ 710, eBioscience™, Invitrogen™

Catalog No. 46538180
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46-538-180 25 μg
46-538-182 100 μg
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Catalog No. 46-538-180 Supplier Invitrogen™ Supplier No. 46538180
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Description

Syrian Hamster Monoclonal Antibody

Podoplanin (PDPN, T1A, gp38, Aggrus) is a mucin type-1 glycoprotein with a 40-43 kDa molecular weight. Podoplanin is expressed in many tumors and normal cells, especially lymphatic epithelial cells and follicular DCs. Podoplanin localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. Podoplanin appears to serve as a ligand for CLEC-2 and expression is positively correlated with tumors expressing greater invasive and metastatic potential. Podoplanin is directly involved in cell migration, aids metastases formation and tumor cell invasion of tissue. Further, it has also been determined that podoplanin expression is induced through Src activation of Cas and, recently, there are indications of podoplanin presence on Th17 cells. Initial studies below indicate the presence of podoplanin on a small but distinct population of CD4+ cells from human PBMC. Dysfunction of the podoplanin protein has been linked to diseases such as lymphangioma and subglottis neoplasm. Podoplanin has also been proposed as a marker for lung injury due to the physiological function of the protein.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Podoplanin
Applications Flow Cytometry
Classification Monoclonal
Clone eBio8.1.1 (8.1.1)
Concentration 0.2 mg/mL
Conjugate PerCP-eFluor 710
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene PDPN
Gene Accession No. Q62011
Gene Alias 29kDa cytosolic podoplanin intracellular domain; Aggrus; CTA-520D8.1; E11; E11 antigen epitope; epithelial cell surface transmembrane protein antigen; glycoprotein 36; Glycoprotein 38; glycoprotein, 36-KD; GP36; Gp38; GP40; HT1A-1; hT1alpha-1; hT1alpha-2; lung type I cell membrane associated glycoprotein; lung type-I cell membrane-associated glycoprotein (T1A-2); Ots8; OTS-8; OTTHUMP00000009640; OTTHUMP00000044504; PA2.26; PA2.26 antigen; PDPN; PICD; Podoplanin; PSEC0003; PSEC0025; pulmonary type I alveolar epithelial cell transmembrane differentiation marker; RANDAM-2; RP23-348F1.2; RTI140; RTI40; T1a; T1A2; T1A-2; T1alpha; T1-alpha; TI1A; Transmembrane glycoprotein E11; type I cell 40 kDa protein
Gene Symbols PDPN
Host Species Syrian Hamster
Purification Method Affinity chromatography
Quantity 25 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14726
Target Species Mouse
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG
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