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Podoplanin Mouse, anti-Human, R718, Clone: LPMAB-17, BD OptiBuild™

Catalog No. BDB752375 Shop All BD Biosciences Products
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BDB752375 50 μg
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Catalog No. BDB752375 Supplier BD Biosciences Supplier No. 752375
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Description

Mouse Monoclonal Antibody

The LpMab-17 monoclonal antibody specifically recognizes human podoplanin which is encoded by PDPN. Podoplanin is a 38-44 kDa type I transmembrane glycoprotein. This heavily glycosylated mucin type protein is named for its expression on kidney glomerular epithelial cells known as podocytes. It is also expressed on a wide variety of cell types, including intestinal and thymic epithelial cells, alveolar type I cells, fibroblastic reticular cells, lymphatic endothelial cells, osteoblasts, and Th17 cells. Its expression is upregulated in some tumors. Podoplanin induces platelet aggregation via its three platelet aggregation-stimulating (PLAG) domains| it binds C-type lectin domain family 1 member B (Clec1B, also known as CLEC2)| and it is involved in actin cytoskeleton organization and in cellular adhesion and migration. It also plays roles in organogenesis, vascular development, inflammatory diseases, tumorigenesis, and cancer cell motility and metastasis.

TRUSTED_SUSTAINABILITY

Specifications

Antigen Podoplanin
Applications Flow Cytometry
Classification Monoclonal
Clone LPMAB-17
Conjugate R718
Host Species Mouse
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Refrigerate Upon Arrival
Form Liquid
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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