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Invitrogen™ POFUT1 Polyclonal Antibody
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Catalog No. PIPA531357
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100 μL
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PIPA531357 100 μL
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Catalog No. PIPA531357 Supplier Invitrogen™ Supplier No. PA531357
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: HCT116, mouse liver, HUVEC, HUVEC treat with Sphingosine 1-phosphate. Predicted reactivity: Mouse (96%), Rat (97%), Dog (93%), Pig (95%), Chimpanzee (100%), Bovine (96%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

POFUT1, an endoplasmic reticulum-residing member of the glycosyltransferase O-Fuc family, adds O-fucose through an O-glycosidic linkage to conserved serine or threonines in epidermal growth factor-like repeats of several cell surface and secreted proteins. Unlike its homolog POFUT2, POFUT1 can also catalyze the transfer of fucose to thrombospondin type 1 repeats. Many of the substrates of POFUT1 are involved in ligand-induced receptor signaling. One such protein is Notch; mouse ES cells lacking POFUT have normal levels of Notch receptors at the cell surface, but these receptors do not bind Notch ligands or exhibit Notch signaling.
TRUSTED_SUSTAINABILITY

Specifications

Antigen POFUT1
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.8 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene POFUT1
Gene Accession No. Q91ZW2, Q9H488
Gene Alias DDD2; FUT12; GDP-fucose protein O-fucosyltransferase 1; KIAA0180; mKIAA0180; o-fucosyltransferase protein; O-Fuc-T; OFUCT1; O-FucT-1; O-FucT-1a; O-FucT-1b; O-FUT; peptide-O-fucosyltransferase 1; Pofut1; pofut1 {ECO:0000312; protein O-fucosyltransferase 1; protein O-fucosyltransferase 1 isoform 1 precursor; protein O-fucosyltransferase 1a; protein O-fucosyltransferase 1b; protein-O-fucosyltransferase 1; RGD:1303001}; zgc:110472
Gene Symbols POFUT1
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human POFUT1. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 140484, 23509
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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