Invitrogen™ POFUT1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA562980

Catalog No. PIPA562980

Description

Immunogen sequence: LPDLKEIQRA VKLWVRSLDA QSVYVATDSE SYVPELQQLF KGKVKVVSLK PEVAQVDLYI LGQADHFIGN CVSSFTAFVK RERDLQGRPS SFFGMD Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 92%.

POFUT1, an endoplasmic reticulum-residing member of the glycosyltransferase O-Fuc family, adds O-fucose through an O-glycosidic linkage to conserved serine or threonines in epidermal growth factor-like repeats of several cell surface and secreted proteins. Unlike its homolog POFUT2, POFUT1 can also catalyze the transfer of fucose to thrombospondin type 1 repeats. Many of the substrates of POFUT1 are involved in ligand-induced receptor signaling. One such protein is Notch; mouse ES cells lacking POFUT have normal levels of Notch receptors at the cell surface, but these receptors do not bind Notch ligands or exhibit Notch signaling.

Specifications

• Antigen: POFUT1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: POFUT1
• Gene Alias: DDD2; FUT12; GDP-fucose protein O-fucosyltransferase 1; KIAA0180; mKIAA0180; o-fucosyltransferase protein; O-Fuc-T; OFUCT1; O-FucT-1; O-FucT-1a; O-FucT-1b; O-FUT; peptide-O-fucosyltransferase 1; Pofut1; pofut1 {ECO:0000312; protein O-fucosyltransferase 1; protein O-fucosyltransferase 1 isoform 1 precursor; protein O-fucosyltransferase 1a; protein O-fucosyltransferase 1b; protein-O-fucosyltransferase 1; RGD:1303001}; zgc:110472
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23509
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9H488
• Gene Symbols: POFUT1
• Immunogen: Recombinant protein corresponding to Human POFUT1. Recombinant protein control fragment (Product #RP-99323).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG