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Invitrogen™ POFUT1 Polyclonal Antibody
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Catalog No. PIPA597014
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100 μL
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PIPA597014 100 μL
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Catalog No. PIPA597014 Supplier Invitrogen™ Supplier No. PA597014
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: SWDPAGYLLY CPCMGRFGNQ ADHFLGSLAF AKLLNRTLAV PPWIEYQHHK PPFTNLHVSY QKYFKLEPLQ AYHRVISLED FMEKLAPTHW PPEKRVAYCF EVAAQRSPDK KTCPMKEGNP FGPFWDQFHV SFNKSELFTG ISFSASYREQ WSQRRENHSC VTLLFPR; Positive Samples: HepG2, HL-60, Mouse heart, Mouse liver; Cellular Location: Endoplasmic reticulum.

POFUT1, an endoplasmic reticulum-residing member of the glycosyltransferase O-Fuc family, adds O-fucose through an O-glycosidic linkage to conserved serine or threonines in epidermal growth factor-like repeats of several cell surface and secreted proteins. Unlike its homolog POFUT2, POFUT1 can also catalyze the transfer of fucose to thrombospondin type 1 repeats. Many of the substrates of POFUT1 are involved in ligand-induced receptor signaling. One such protein is Notch; mouse ES cells lacking POFUT have normal levels of Notch receptors at the cell surface, but these receptors do not bind Notch ligands or exhibit Notch signaling.
TRUSTED_SUSTAINABILITY

Specifications

Antigen POFUT1
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.71 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene POFUT1
Gene Accession No. Q6EV70, Q91ZW2, Q9H488
Gene Alias DDD2; FUT12; GDP-fucose protein O-fucosyltransferase 1; KIAA0180; mKIAA0180; o-fucosyltransferase protein; O-Fuc-T; OFUCT1; O-FucT-1; O-FucT-1a; O-FucT-1b; O-FUT; peptide-O-fucosyltransferase 1; Pofut1; pofut1 {ECO:0000312; protein O-fucosyltransferase 1; protein O-fucosyltransferase 1 isoform 1 precursor; protein O-fucosyltransferase 1a; protein O-fucosyltransferase 1b; protein-O-fucosyltransferase 1; RGD:1303001}; zgc:110472
Gene Symbols POFUT1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 28-194 of human POFUT1 (NP_7584361).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 140484, 23509, 311551
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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