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POLB Monoclonal Antibody (18S), Invitrogen™

Catalog No. PIMA513899
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500 μL
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Catalog No. Quantity
PIMA513899 500 μL
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Catalog No. PIMA513899 Supplier Thermo Scientific Supplier No. MA513899
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Description

Mouse Monoclonal Antibody

MA5-13899 targets Rat DNA Polymerase beta in IP and WB applications and shows reactivity with Bovine, Hamster, Human, mouse, Rat, and Xenopus laevis samples. The MA5-13899 immunogen is rat DNA polymerase beta protein.

DNA polymerase beta comprises an amino-terminal 8- kDa domain and a carboxy-terminal 31- kDa domain. The N-terminal ssDNA binding domain has a deoxyribose phosphodiesterase activity while the C-terminal domain has a nucleotidyltransferase activity. Mammalian DNA polymerase beta, a DNA repair polymerase, is constitutively expressed in cultured cells, but treatment of cells with the DNA-alkylating agents such as N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) or methyl methanesulfonate up-regulates beta-pol level. DNA polymerase beta fills single nucleotide gaps in DNA produced by the base excision repair pathway of mammalian cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen POLB
Applications Immunoprecipitation, Western Blot
Classification Monoclonal
Clone 18S
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
Gene POLB
Gene Accession No. O57383, P06746, P06766, Q27958, Q8K409
Gene Alias A430088C08Rik; DNA pol beta; DNA polymerase beta; DNA polymerase beta subunit; DNA-directed DNA polymerase beta; hypothetical protein LOC614688; LOW QUALITY PROTEIN: DNA polymerase beta; MGC125976; POL B; Pol beta; POLB; polb.S; polymerase (DNA directed), beta; polymerase (DNA directed), beta S homeolog; polymerase (DNA) beta; polymerase B; polymerase-beta; wu:fa97a05; XELAEV_18020165mg; zgc:109924
Gene Symbols POLB, polb.S
Host Species Mouse
Immunogen Rat DNA polymerase beta protein
Purification Method Protein G
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100774965, 18970, 29240, 397973, 5423, 614688
Target Species Bovine, Hamster, Human, Mouse, Rat, X. laevis
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG1
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