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Invitrogen™ POLB Recombinant Rabbit Monoclonal Antibody (JM93-12)
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Catalog No. PIMA532724
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PIMA532724 100 μL
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Catalog No. PIMA532724 Supplier Invitrogen™ Supplier No. MA532724
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Description

Rabbit Recombinant Monoclonal Antibody

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

DNA polymerase beta comprises an amino-terminal 8- kDa domain and a carboxy-terminal 31- kDa domain. The N-terminal ssDNA binding domain has a deoxyribose phosphodiesterase activity while the C-terminal domain has a nucleotidyltransferase activity. Mammalian DNA polymerase beta, a DNA repair polymerase, is constitutively expressed in cultured cells, but treatment of cells with the DNA-alkylating agents such as N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) or methyl methanesulfonate up-regulates beta-pol level. DNA polymerase beta fills single nucleotide gaps in DNA produced by the base excision repair pathway of mammalian cells.
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Specifications

Antigen POLB
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry, Western Blot
Classification Recombinant Monoclonal
Clone JM93-12
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide; pH 7.4
Gene POLB
Gene Accession No. P06746, P06766, Q6DRD3, Q8K409
Gene Alias A430088C08Rik; DNA pol beta; DNA polymerase beta; DNA polymerase beta subunit; DNA-directed DNA polymerase beta; hypothetical protein LOC614688; LOW QUALITY PROTEIN: DNA polymerase beta; MGC125976; POL B; Pol beta; POLB; polb.S; polymerase (DNA directed), beta; polymerase (DNA directed), beta S homeolog; polymerase (DNA) beta; polymerase B; polymerase-beta; wu:fa97a05; XELAEV_18020165mg; zgc:109924
Gene Symbols POLB
Host Species Rabbit
Immunogen Synthetic peptide within Human DNA Polymerase beta aa 286-335.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18970, 29240, 5423, 554204
Target Species Human, Mouse, Rat, Zebrafish
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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