PolD3/p66 Rabbit anti-Human, Polyclonal, Bethyl Laboratories 

Rabbit Polyclonal Antibody

Manufacturer:  Bethyl Laboratories, Inc A301243AT

Catalog No. 50-155-9867

Description

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

DNA replication, recombination and repair, all of which are necessary for genomic stability, require the presence of exonucleases. In DNA replication, exonucleases are involved in the processing of Okazaki fragments, whereas in DNA repair, they function to excise damaged DNA fragments and correct recombinational mismatches. These exonucleases include the family of DNA polymerases, namely DNA pol alpha, beta, delta and epsilon. DNA pol delta and DNA pol epsilon are multisubunit enzymes, with DNA pol delta consisting of two subunits which interact with the sliding DNA clamp protein PCNA. DNA pol delta 3, also known as POLD3 or p66, is a 466 amino acid nuclear protein that is required for the proper function of DNA pol delta.

Specifications

• Antigen: PolD3/p66
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: POLD3
• Format: liquid
• Gene Symbols: POLD3
• Immunogen: Between 325 and 375
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Type: Antibody
• Monoclonal or Polyclonal: Polyclonal
• Target Species: Human

• Applications: Immunohistochemistry, Immunoprecipitation
• Concentration: 1 mg/ml
• Formulation: phosphate, tris citrate with 0.09% sodium azide; pH 7-8
• Gene Accession No.: Q15054
• Gene Alias: DNA polymerase delta subunit 3, DNA polymerase delta subunit p66, POLD3, KIAA0039, DNA pol delta3, DNA pol delta3, DNApol delta3, DNA pol delta p66, DNA pol delta p66
• Host Species: Rabbit
• Isotype: IgG
• Quantity: 10 μl
• Storage Requirements: 4° C
• Primary or Secondary: Primary
• Gene ID (Entrez): 10714