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Invitrogen™ POLD3 Polyclonal Antibody
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Catalog No. PIPA596616
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100 μL
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PIPA596616 100 μL
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Catalog No. PIPA596616 Supplier Invitrogen™ Supplier No. PA596616
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: ASKAAAKTQE TNKETKTEAK EVTNASAAGN KAPGKGNMMS NFFGKAAMNK FKVNLDSEQA VKEEKIVEQP TVSVTEPKLA TPAGLKKSSK KAEPVKVLQK EKKRGKRVAL SDDETKETEN MRKKRRRIKL PESDSSEDEV FPDSPGAYEA ESPSPPPPPS PPLEPVPKTE PEPPSVKSSS GENKRKRKRV LKSKTYLDGE GCIVTEKVYE SESCTDSEEE LNMKTSSVHR PPAMTVKKEP REERKGPKKG TAALGKANRQ VSITGFFQRK; Positive Samples: THP-1, HepG2, HeLa, MCF7, H460, Mouse brain; Cellular Location: Nucleus.

DNA replication, recombination and repair, all of which are necessary for genomic stability, require the presence of exonucleases. In DNA replication, exonucleases are involved in the processing of Okazaki fragments, whereas in DNA repair, they function to excise damaged DNA fragments and correct recombinational mismatches. These exonucleases include the family of DNA polymerases, namely DNA pol alpha, beta, delta and epsilon. DNA pol delta and DNA pol epsilon are multisubunit enzymes, with DNA pol delta consisting of two subunits which interact with the sliding DNA clamp protein PCNA. DNA pol delta 3, also known as POLD3 or p66, is a 466 amino acid nuclear protein that is required for the proper function of DNA pol delta.
TRUSTED_SUSTAINABILITY

Specifications

Antigen POLD3
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry, Western Blot
Classification Polyclonal
Concentration 0.41 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene POLD3
Gene Accession No. Q15054, Q9EQ28
Gene Alias 2410142G14Rik; C85233; DNA pol delta3; DNA polymerase delta 3, accessory subunit; DNA polymerase delta subunit 3; DNA polymerase delta subunit C; DNA polymerase delta subunit p66; DNA polymerase delta subunit p68; DNA-directed DNA polymerase delta 3; DNApol delta3; GC12; KIAA0039; P66; P68; Pol delta C subunit (p66); POLD3; polymerase (DNA directed), delta 3; polymerase (DNA) delta 3, accessory subunit; polymerase (DNA-directed), delta 3, accessory subunit; PPP1R128; protein phosphatase 1, regulatory subunit 128
Gene Symbols POLD3
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 197-466 of human POLD3 (NP_0065821).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10714, 67967
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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