Invitrogen™ POLE3 Monoclonal Antibody (3C5.1)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA116509

Catalog No. AMPA6509

Description

This antibody does not detect drosophilia or the baculovirus host cell pol epsilon, and weakly, if at all, on s.cerivisae pol epsilon.

Mitochondrial creatine kinase (MtCK) is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Sarcomeric mitochondrial creatine kinase has 80% homology with the coding exons of ubiquitous mitochondrial creatine kinase. This gene contains sequences homologous to several motifs that are shared among some nuclear genes encoding mitochondrial proteins and thus may be essential for the coordinated activation of these genes during mitochondrial biogenesis. Three transcript variants encoding the same protein have been found for this gene.

Specifications

• Antigen: POLE3
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q9JKP7, Q9NRF9
• Gene Symbols: POLE3
• Immunogen: Mono S FPLC column purified HeLa cell polymerase epsilon.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Monkey, Mustelid
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Clone: 3C5.1
• Conjugate: Unconjugated
• Gene: POLE3
• Gene Alias: 1810034K18Rik; arsenic transactivated protein; arsenic-transactivated protein; AsTP; CHARAC17; CHRAC 17; CHRAC17; CHRAC-17; Chromatin accessibility complex 17 kDa protein; DNA polymerase epsilon 3, accessory subunit; DNA polymerase epsilon p17 subunit; DNA polymerase epsilon subunit 3; DNA polymerase epsilon subunit p17; DNA polymerase epsilon, subunit 3; DNA polymerase II subunit 3; DNA-directed DNA polymerase epsilon 3; histone fold protein CHRAC17; huCHRAC17; NF-YB-like protein; p17; Pole3; polymerase (DNA directed), epsilon 3 (p17 subunit); polymerase (DNA directed), epsilon 3, accessory subunit; polymerase (DNA) epsilon 3, accessory subunit; YBL1; YB-like protein 1
• Host Species: Mouse
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 54107, 59001
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid