POLI Mouse anti-Human, Clone: OTI1C8, lyophilized, TrueMAB™ 

Mouse Monoclonal Antibody

Manufacturer:  OriGene CF801478

Catalog No. 50-166-5609

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5 ft.-deoxyribose phosphate at abasic sites, but may not have lyase activity.

Specifications

• Antigen: POLI
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: POLI
• Format: Lyophilized
• Gene Symbols: POLI
• Immunogen: Human recombit protein fragment corresponding to amino acids 458-740 of human POLI produced in E.coli.
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Type: Antibody
• Monoclonal or Polyclonal: Monoclonal
• Target Species: Human

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI1C8
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: Q9UNA4
• Gene Alias: RAD30B, RAD3OB, eta2
• Host Species: Mouse
• Isotype: IgG1
• Quantity: 100 μg
• Storage Requirements: -20° C, Avoid Freeze/Thaw Cycles
• Primary or Secondary: Primary
• Gene ID (Entrez): 11201