POLI Mouse anti-Human, Clone: OTI1C8, lyophilized, TrueMAB
Mouse Monoclonal Antibody
Manufacturer: OriGene CF801478
Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCOError-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5 ft.-deoxyribose phosphate at abasic sites, but may not have lyase activity.
|Human recombit protein fragment corresponding to amino acids 458-740 of human POLI produced in E.coli.|
|Immunohistochemistry (Paraffin), Western Blot|
|PBS with 8% trehalose and no preservative; pH 7.3|
|RAD30B, RAD3OB, eta2|
|-20° C, Avoid Freeze/Thaw Cycles|
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