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Invitrogen™ POLI Polyclonal Antibody
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Catalog No. PIPA5102527
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100 μL
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PIPA5102527 100 μL
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Catalog No. PIPA5102527 Supplier Invitrogen™ Supplier No. PA5102527
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total POLI.

Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunoglobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen POLI
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Poli
Gene Accession No. Q6R3M4, Q9UNA4
Gene Alias DNA polymerase iota; eta2; Poli; polymerase (DNA directed) iota; polymerase (DNA directed), iota; polymerase (DNA) iota; polymerase (DNA-directed), iota; RAD 30B; RAD30; RAD30 homolog B; RAD30B; RAD3OB
Gene Symbols Poli
Host Species Rabbit
Immunogen A synthesized peptide derived from human POLI(Accession Q9UNA4), corresponding to amino acid residues M1-N49.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11201, 26447, 291526
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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