POLKGoat anti-Human, Polyclonal, Rockland™

Catalog No.	Quantity
50-199-1565	100 μg

Catalog No. 50-199-1565 Supplier Rockland Immunochemicals Supplier No. 600101295

Description

Goat Polyclonal Antibody

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. This affinity purified antibody is directed against human POLK protein. A BLAST analysis was used to suggest reactivity with this protein from human, chimpanzee and orangutan based on 100% homology for the immunogen sequence. Cross reactivity with POLK protein from mouse is expected, as this sequence is highly homologous in human and mouse. Expect reactivity with multiple splice variants of this protein. Cross reactivity with POLK homologues from other sources has not been determined.

External and internal DNA-damaging agents continually threaten the integrity of genetic material in cells. Although a variety of repair mechanisms exist to remove the resulting lesions, some lesions escape repair and block the replication machinery. Members of the Y family of DNA polymerases, such as POLK, permit the continuity of the replication fork by allowing replication through such DNA lesions. Each Y family polymerase has a unique DNA-damage bypass and fidelity profile. POLK is specialized for the extension step of lesion bypass.

Specifications

• Antigen: POLK
• Applications: ELISA, Immunoprecipitation, Western Blot
• Classification: Polyclonal
• Concentration: 1.4 mg/mL
• Conjugate: Unconjugated
• Formulation: 0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
• Gene: POLK
• Gene Accession No.: Q9UBT6
• Gene Alias: BOS_10072; DinB homolog 1; DINB protein; DINB1; DINP; DNA damage-inducible protein b; DNA polymerase kappa; DNA-directed DNA polymerase kappa; Polk; POLQ; polymerase (DNA directed) kappa; polymerase (DNA directed), kappa; polymerase (DNA) kappa
• Gene Symbols: POLK
• Host Species: Goat
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 51426
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid