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POLR1A Rabbit anti-Human, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 205951AP

Catalog No. 50-173-2979


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Description

Description

SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.
Specifications

Specifications

POLR1A
0.31 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
O95602
A190, POLR1A, RNA polymerase I subunit A1, RPA1, RPA194, RPO1 4
Rabbit
IgG
150 μL
-20°C
Primary
25885
Immunoprecipitation, Western Blot
Unconjugated
POLR1A
Liquid
POLR1A
POLR1A Fusion Protein Ag14543
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human
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