Invitrogen™ POLR3D Monoclonal Antibody (4E6)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA518491

Catalog No. PIMA518491

Description

Peptide Sequence: GQVVLIKQEK DREAKLAENA CTLADLTEGQ VGKLLIRKSG RVQLLLGKVT LDVTMGTACS FLQELVSVGL GDSRTGEMTV LGHVKHKLVC SPDFESLLDH.

This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer.

Specifications

• Antigen: POLR3D
• Classification: Monoclonal
• Concentration: 0.2-1.0 mg/mL
• Formulation: PBS with no preservative; pH 7.4
• Gene Accession No.: P05423
• Gene Symbols: Polr3d
• Immunogen: POLR3D (-, 296 a.a. ~ 395 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a κ

• Applications: ELISA
• Clone: 4E6
• Conjugate: Unconjugated
• Gene: Polr3d
• Gene Alias: 2810426M17Rik; 44kDa; AI326118; AW489084; BN51; BN51 (BHK21) temperature sensitivity complementing; Bn51t; DNA-directed RNA polymerase III 47 kDa polypeptide; DNA-directed RNA polymerase III subunit C4; DNA-directed RNA polymerase III subunit D; DNA-directed RNA polymerase III subunit RPC4; HOX1C; Polr3d; polymerase (RNA) III (DNA directed) polypeptide D; polymerase (RNA) III (DNA directed) polypeptide D, 44kDa; polymerase (RNA) III subunit D; Protein BN51; RNA polymerase III 47 kDa subunit; RNA polymerase III subunit C4; RNA polymerase III subunit D; RPC4; RPC53; RPC53 homolog; temperature sensitive complementation, cell cycle specific, tsBN51; TSBN51
• Host Species: Mouse
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 661
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid