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Invitrogen™ POLR3G Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA551120

Catalog No. PA551120


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Description

Description

POLR3G Polyclonal Antibody detects endogenous levels of POLR3G protein.

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. POLR3G is a specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. It may direct with other members of the RPC3/POLR3C-RPC6/POLR3F-RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. It may be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. POLR3G plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. POLR3G acts as nuclear and cytosolic DNA sensor involved in innate immune response. POLR3G can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

POLR3G
Polyclonal
Unconjugated
POLR3G
2310047G20Rik; AV275904; DNA-directed RNA polymerase III 32 kDa polypeptide; DNA-directed RNA polymerase III subunit G; DNA-directed RNA polymerase III subunit RPC7; Polr3g; polymerase (RNA) III (DNA directed) polypeptide G; polymerase (RNA) III (DNA directed) polypeptide G (32kD); polymerase (RNA) III subunit G; RNA polymerase III 32 kDa apha subunit; RNA polymerase III 32 kDa subunit; RNA polymerase III subunit C7; RNA polymerase III subunit G; RPC32; RPC32-alpha; RPC7
Rabbit
Antigen Affinity Chromatography
RUO
10622, 67486
-20°C, Avoid Freeze/Thaw Cycles
Liquid
Western Blot
1 mg/mL
PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
O15318, Q6NXY9
POLR3G
Synthesized peptide derived from the Internal region of human POLR3G (aa 151-200).
100 μL
Primary
Human, Mouse
Antibody
IgG
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