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Invitrogen™ POLR3G Polyclonal Antibody
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Catalog No. PIPA5103799
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100 μL
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PIPA5103799 100 μL
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Catalog No. PIPA5103799 Supplier Invitrogen™ Supplier No. PA5103799
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total RPC7.

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. POLR3G is a specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. It may direct with other members of the RPC3/POLR3C-RPC6/POLR3F-RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. It may be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. POLR3G plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. POLR3G acts as nuclear and cytosolic DNA sensor involved in innate immune response. POLR3G can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.
TRUSTED_SUSTAINABILITY

Specifications

Antigen POLR3G
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene POLR3G
Gene Accession No. O15318
Gene Alias 2310047G20Rik; AV275904; DNA-directed RNA polymerase III 32 kDa polypeptide; DNA-directed RNA polymerase III subunit G; DNA-directed RNA polymerase III subunit RPC7; Polr3g; polymerase (RNA) III (DNA directed) polypeptide G; polymerase (RNA) III (DNA directed) polypeptide G (32kD); polymerase (RNA) III subunit G; RNA polymerase III 32 kDa apha subunit; RNA polymerase III 32 kDa subunit; RNA polymerase III subunit C7; RNA polymerase III subunit G; RPC32; RPC32-alpha; RPC7
Gene Symbols POLR3G
Host Species Rabbit
Immunogen A synthesized peptide derived from human POLR3G(Accession O15318), corresponding to amino acid residues F14-L64.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10622
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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