POLR3H Mouse anti-Human, Clone: OTI4D8, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF809432

Catalog No. 50-166-9489

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

RPC8 is DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. It is plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. It is acting as nuclear and cytosolic DNA sensor involved in innate immune response. It can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-Kappa-B through the RIG-I pathway.

Specifications

• Antigen: POLR3H
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: POLR3H
• Gene Alias: RPC22.9, RPC8
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 171568
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI4D8
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: Q9Y535
• Gene Symbols: POLR3H
• Immunogen: Full length human recombit protein of human POLR3H produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1